Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2016,（11）
• 页码范围: 1260-1263
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2016.116

摘要

Dear Editor, Since ZIKV outbreak was first reported in South and Central America and the Caribbean,it has spread to both North America and Asia [1].Preliminary reports have now estimated as many as 1.3 million cases of infection in this widespread epidemic [2].Initially it was thought that the ZIKV only causes mild symptoms such as fever,myalgia,and rash;recent studies have revealed that ZIKV can also cause severe neurological pathologies such as neonatal microcephaly and Guillain-Barre syndrome [3].