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AIM: To evaluate the effect of sodium tungstate on visual evoked potentials(VEPs) in diabetic rats.· METHODS: Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin(50 mg/kg). Sodium tungstate [40 mg/(kg·d)]was administered for 12 wk and then VEPs were recorded.Additionally, thiobarbituric acid reactive substance(TBARS) levels were measured in brain tissues.·RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group.· CONCLUSION: Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use.
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篇名 Effect of sodium tungstate on visual evoked potentials in diabetic rats
来源期刊 国际眼科杂志:英文版 学科 医学
关键词 DIABETES RETINOPATHY sodium tungstate visual evoked potentials lipid peroxidation
年,卷(期) 2016,(5) 所属期刊栏目
研究方向 页码范围 677-681
页数 5页 分类号 R77
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研究主题发展历程
节点文献
DIABETES
RETINOPATHY
sodium
tungstate
visual
evoked
potentials
lipid
peroxidation
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研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
国际眼科杂志:英文版
月刊
2222-3959
西安市友谊东路269号
出版文献量(篇)
2720
总下载数(次)
2
总被引数(次)
0
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