4-63 Suppression of Radiation-induced Migration of Non-small Cell Lung Cancer through Inhibition of Nrf2-Notch Axis

• 作者: Zhang Hong Zhao Qiuyue
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报：英文版
• 学科: 物理学
• 年，卷（期）: 2016,（1）
• 页码范围: 189-189
• 页数: 1页
• 分类号: O4

摘要

Nuclear factor E2 related factor 2(Nrf2)is a transcription factor that is associated with tumor growth and resistance to radiation.The canonical Notch signaling pathway is also crucial for maintaining non-small cell lung cancer(NSCLC).Aberrant Nrf2 and Notch signaling has repeatedly been showed to facilitate metastasis of NSCLC.Here,we show that radiation induce Nrf2 and Notch1 expression in NSCLC.Knockdown of Nrf2 enhanced radiosensitivity of NSCLC and reduced epithelial-to-mesenchymal transition.Importantly,we found that knockdown of Nrf2 dramatically decreased radiation-induced NSCLC invasion(Fig.1)and significantly increased E-cadherin,but reduced N-cadherin and matrix metalloproteinase(MMP)-2/9 expression.