The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population

• 作者: Bin Lu Hui-Hui Wu Jie Wen Nai-Jia Liu Qian Xiong Ren-Ming Hu Xiao-Ming Tao Xuan-Chun Wang Yan-Liang Li Yan-Ping Du Zhen Yang
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: CDKAL1 POLYMORPHISM association analysis diabetic retinopathy Chinese Han population
• 年，卷（期）: 2016,（5）
• 页码范围: 707-712
• 页数: 6页
• 分类号: R77

摘要

AIM: To identify the contribution of CDKAL1 to the development of diabetic retinopathy(DR) in Chinese population.·METHODS: A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus(T2DM). A welldefined population with T2 DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant(rs10946398) of CDKAL1. Genotyping was performed by i PLEX technology. The association between rs10946398 and T2 DM was assessed by univariate and multivariate logistic regression(MLR) analysis.· RESULTS: There were significant differences in C allele frequencies of rs10946398(CDKAL1) between control and DR groups(45.06% versus 55.00%, P <0.05).The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.·CONCLUSION: Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.