Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus

• 作者: Erdinc Aydin Semsettin Sahin
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: aqueous humor diabetes mellitus diabetic retinopathy MELATONIN
• 年，卷（期）: 2016,（5）
• 页码范围: 721-724
• 页数: 4页
• 分类号: R77

摘要

AIM: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy(DR) grade in type 2 diabetic patients.·METHODS: Aqueous humor and plasma samples from26 patients with DR(in nonproliferative and proliferative stages) and 14 control subjects were collected during cataract surgery after 6 p.m. Melatonin concentrations were determined using an enzyme-linked immunosorbent assay(ELISA).·RESULTS: Melatonin levels were significantly higher in the aqueous humor of patients with proliferative diabetic retinopathy(PDR) [18.57 ±2.67 pg/m L(range 15.20-23.06)vs 13.63±2.71 pg/m L(range 10.20-20.20), P =0.0001], but not in those with nonproliferative retinopathy(NPDR)[13.79±2.56 pg/m L(range 9.80-20.10) vs 13.63±2.71 pg/m L(range 10.20-20.20), P =0.961] compared to controls. There was decrement in the plasma melatonin level of patients with PDR, but no significant differences between the plasma melatonin levels of the study groups [ 5. 37 ±1.74 pg/m L(range 2.85-8.65) vs 6.11±1.90 pg/m L(range3.13-9.41), P =0.293], or between control and DR groups[NPDR 6.11 ±1.90 pg/m L(range 3.13-9.41) vs control6.15±1.91 pg/m L(range 2.18-9.86); PDR(5.37±1.74 pg/m L(range 2.85-8.65) vs control 6.15 ±1.91 pg/m L(range2.18-9.86), P =0.808, P =0.264].·CONCLUSION: Elevated melatonin levels in aqueous humor in PDR may indicate the level to be associated with DR severity.