Molecular underpinnings of corneal angiogenesis：advances over the past decade

• 作者: Amira A.Zayed Heba Hussein Mohamed Amgad Nawal AbdEl-Baky Nizar Saleh Abdelfattah
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: CORNEA NEOVASCULARIZATION ANGIOGENESIS LYMPHANGIOGENESIS vascular endothelial growth factor
• 年，卷（期）: 2016,（5）
• 页码范围: 768-779
• 页数: 12页
• 分类号: R77

摘要

The cornea is maintained in an avascular state by maintaining an environment whereby anti-angiogenic factors take the upper hand over factors promoting angiogenesis. Many of the common pathologies affecting the cornea involve the disruption of such equilibrium and the shift towards new vessel formation, leading to corneal opacity and eventually-vision loss. Therefore it is of paramount importance that the molecular underpinnings of corneal neovascularization(CNV) be clearly understood, in order to develop better targeted treatments. This article is a review of the literature on the recent discoveries regarding pro-angiogenic factors of the cornea(such as vascular endothelial growth factors,fibroblast growth factor and matrix metalloproteinases)and anti-angiogenic factors of the cornea(such as endostatins and neostatins). Further, we review the molecular underpinnings of lymphangiogenesis, a process now known to be almost separate from(yet related to) hemangiogenesis.