As the disadvantages of large scale,complex circuit,high power consumption,the traditional readout electronics system formed by discrete modules is not suitable for the TOF-PET system,a nuclear medical imaging system.Therefore,it is necessary to design and develop a new high integration and low cost readout electronics system for TOF-PET.A readout electronics system for our prototype of TOF-PET has been developing on the basis of application requirements.The principle architecture of prototype of TOF-PET is shown in Fig.1.There are five parts mainly in the system:the detector unit,the front-end electronics module(FEM),signal processing board(SPB),Coincidence Interface Board(CI),and PC.The FEM and SPB boards developed until now are mainly introduced in this paper.