Histopathological changes in retinas and F-ERG features of streptozotocin-induced diabetic rats treated with ozone

• 作者: Qin Li Ting-Yu Xie Xue-Yi Chen
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: diabetic rat retina ozone treatment histopathological changes flash electroretinogram features
• 年，卷（期）: gjykzzywb_2016,（6）
• 页码范围: 816-820
• 页数: 5页
• 分类号: R77

摘要

AIM: To study the histopathological changes in the retina and flash electroretinogram(F-ERG) features of ozone-treated streptozotocin(STZ)-induced diabetic rats.METHODS: Seventy male Sprague Dawley rats were grouped as follows: blank group(GB, n =10), model control group(GM, n =18), ozone group(GO3, n =19), and oxygen group(GO2, n =18). The model was induced by single intraperitoneal injection of STZ. Ozone or oxygen enteroclysm was given twice per week for 4wk. F-ERG and histopathological examinations were performed one month after treatment.RESULTS: Under dark adaption, as compared to GB,the other groups each had differential decreases in the a-wave amplitudes(P <0.05); the latencies were delayed in GM, GO2, and GO3rats(P <0.05). Similar results were observed under light adaption, with the exception that the a-wave of the amplitudes(F =0.28, P >0.05). There were significant differences in the apoptosis index among the groups(P <0.05). Under ozone treatment,apoptosis was decreased in GO3 as compared to GM and GO2.CONCLUSION: Ozone administration alleviates nerve damage and reduces pathology and apoptosis in the retinas of diabetic rats.