Histopathologic effects of a low molecular weight heparin on bone healing in rats： a promising adjuvant in dacryocystorhinostomy

• 作者: Ahmet Ucaner Mehmet Numan Alp Mustafa Fevzi Sargon Ozdamar Fuad Oken
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: DACRYOCYSTORHINOSTOMY ENOXAPARIN wound healing low molecular weight heparin
• 年，卷（期）: gjykzzywb_2016,（6）
• 页码范围: 838-842
• 页数: 5页
• 分类号: R77

摘要

AIM: To investigate the effect of short-term prophylactic dose of a low molecular weight heparin(LMWH) drug on the bone healing process in an animal model simulating the osteotomy obtained in dacryocystorhinostomy.METHODS: Forty male Wistar albino rats were divided into 2 groups. Subcutaneous injections of enoxaparin1 mg/kg(enoxaparin-treated group) and saline solution(control group) were performed once daily for 4d,beginning on the first preoperative day. The osteotomy was created at the femoral diaphysis in all animals by using a Kirschner wire. Each group was further divided into 2 subgroups depending on the timing of the second operation, 14 or 21 d following initial osteotomy. Patent osteotomy area on the second and the third weeks in each group were calculated by using a computer software on digital micrographs.RESULTS: The patent osteotomy areas at the second and the third weeks were significantly larger in the enoxaparin-treated group than those of the control group(P <0.001 for each time-period). In the control group, the patent osteotomy area at the third week of healing was significantly smaller than that of the second week(P =0.003), whereas there was no significant difference between these two measurements in the enoxaparin-treated group(P =0.185). CONCLUSION: Short-term administration of enoxaparin resultes in a significant alteration in bone healing at 14 and 21 d after injury. LMWHs can be regarded as promising alternative adjuvants in dacryocystorhinostomy after being evaluated with further clinical and animal studies.