Tracheal microenvironment, ANP metabolism and airway tone

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2016,（20）
• 页码范围: 1551-1554
• 页数: 4页
• 语种: 中文
• DOI: 10.1007/s11434-016-1170-3

摘要

Asthma is a chronic inflammatory disease,characterized by reversible airflow obstruction and airway hyperresponsiveness.There has been a sharp increase in the prevalence,morbidity,mortality and ecxnomic burden associated with this disorder over the last several decades,which triggers the development of various antiasthmatic agents [1].Maintenance of airway tone is the key in asthma therapy.This role is currently performed by bronchodilators.β2-adrenoceptor (β2-AR) agonists are gold standard asthma therapeutics,resulting in bronchodilation via the β2-AR-cyclic adenosine monophosphate (cAMP) signaling.