Inhibiting the effect of ^90Sr-^90Y ophthalmic applicators on rat corneal neovascularization induced by sutures

• 作者: Hong Zhang Hong-Yan Zhou Ling Wang Shuang Wang Wen-Song Zhang
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: 2016,（9）
• 页码范围: 1251-1254
• 页数: 4页
• 分类号: R77

摘要

AIM:To investigate a practical technique used to inhibit corneal angiogenesis with a ~(90)Sr-~(90)Y ophthalmic applicator.METHODS:A ~(90)Sr-~(90)Y ophthalmic applicator was detected with a radioactive nuclide application treatment healthy protection standard.The applicator used was produced through medical dosimetry research;it had a concave applicator add measured the applicator temperature,serviceable humidity range,applicator appearance status,applicator radiation homogeneity,radioautography,and radiological safety of the original applicator surface.A vessel model was established using newborn rats,with sutures around the corneal limbus.Corneal neovascularization(CNV) were observed with a slit lamp.The new vessel length and response area were measured.RESULTS:Low-dose radiation can inhibit CNV after corneal sutures.The absorbed dose of the applicator(0.046 Gy/s) was safe for the treatment of it.The lengths of new vessels and the areas of new vessels were lower than the new born vessel rat group(P<0.01).CONCLUSION:The optimal radiation dose emitting from the applicator can be safe and potentially used in humans.