Prevalence and characteristics of ophthalmological extra-intestinal manifestations in Chinese patients with inflammatory bowel disease

• 作者: Chang-Rui Wu Chen Mi Li Ren Wei-Zhi Li Yang Li Ying-Chao Li Yun Feng
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: 2016,（10）
• 页码范围: 1476-1479
• 页数: 4页
• 分类号: R77

摘要

AIM:To investigate the prevalence of ophthalmological extra-intestinal manifestations(O-EIMs) in Chinese patients with inflammatory bowel disease(IBD) and to identify risk factors for the development of O-EIMs.METHODS:The study population consisted of Chinese patients with a definite diagnosis of Crohn's disease(CD) or ulcerative colitis(UC) in a large teaching hospital between January 1995 and December 2014.Demographic and clinical characteristics of patients were extracted retrospectively.RESULTS: In this twenty-year cohort,645 IBD patients(517 with UC,128 with CD) were registered.Among them122(18.9%) exhibited at least one EIM.Of 13 patients(2.0%) developed O-EIMs,7 of CD(5.5%) and 6 of UC(1.2%).Clinical ophthalmological manifestations included redness(76.9%),burning(61.5%),pain(38.5%),itching(15.4%) of eyes and vision change(7.7%).O-EIMs included episcleritis(7),uveitis(5) and dry eye(1).OEIMs were more prevalent in female(odds ratio for male0.61,95% confidence interval 0.52-0.73,P <0.0001),and patients who had IBD diagnosis at young age(odds ratio for patients aged >30 years 0.76,95% confidence interval0.65-0.88,P <0.0001).CONCLUSION: The frequency of O-EIMs in Chinese patients with IBD is lower than the rates reported in the studies of European and American countries.Episcleritisand uveitis are the most common O-EIMs.O-EIMs are more frequent in patients with CD and more prevalent in female and patients who have IBD diagnosis at young age.