This report described a case of the invasive fungal sinusitis cased by asperigillus.A 51 years old women patient complained a sense of welling on right facial,mild pain.No complain of facial numbness and toothache.During the 2 months the symptom repeatedly occurrence.A combined treatment including endoscopic sinus surgery (ESS) and anti-fungal therapy was performed in a patient with invasive fungal rhino-sinusitis.After 3 months of operation,the patient recovered well.No recurrence、no jaw facial pain and swelling,no eye movement disorder.