摘要:
目的:观察长期持续正压通气治疗(continuous positive airway pressure treatment,CPAP)对OSAHS患者血清氧化应激指标(MDA,SOD,GSH-PX)的影响.方法:收集于赣州市人民医院确诊为单纯鼾症13例,轻度OSAHS患者16例,中度OSAHS患者15例,重度OSAHS患者24例.分别检测4组患者清晨空腹血清氧化应激指标(MDA,SOD,GSH-PX)水平,比较4组患者血清氧化应激指标(MDA,SOD,GSH-PX)差异.对中重度OSAHS患者(平均AHI 55.89±17.83次/分,男性96.5%)行CPAP治疗半年,然后复测患者血清MDA,SOD,GSH-PX水平,比较OSAHS患者经CPAP治疗后血清氧化应激指标(MDA,SOD,GSH-PX)的改变情况.结果:从单纯鼾症到重度OSAHS组,患者血清MDA随着病情严重程度加重而升高,血清SOD,GSH-PX随着病情严重程度加重而降低.经CPAP治疗半年后,患者血清MDA,SOD,GSH-PX水平较治疗前明显好转(均P<0.01).结论:OSAHS患者存在氧化应激反应;长期CPAP治疗可减轻OSAHS患者氧化应激反应.