Role of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor regulation in stress-induced pain chronification

• 作者: Feng Tao Sufang Liu
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: -amino-3-hydroxy-5-methyl-4-isoxazole-propionic 酸受体 phosphorylation 应力 疼痛 chronification
• 年，卷（期）: 2017,（1）
• 页码范围: 1-3
• 页数: 3页
• 分类号: R619

摘要

Persistent postsurgical pain is a serious issue in public health, which has received increased interest in recent years. Previous studies have reported that psychological factors promote the development of chronic postsurgical pain. However, it is unclear how chronification of postsurgical pain occurs. The α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor(AMPA) phosphorylation in the central nervous system plays a critical role in synaptic plasticity and contributes to central sensitization and chronic pain development. Here, we discuss the role of AMPA receptor regulation in stress-induced pain chronification after surgery.