Management of unstable angina in a patient with Haemophilia A

• 作者: Andreina Carbone Donato Tartaglione Enrica Golia Felice Gragnano Francesco Natale Maria Giovanna Russo Mario Crisci Maurizio Cappelli Bigazzi Paolo Calabrò Raffaele Calabrò Renato Maria Bianchi Tiziana Formisano
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: HEMOPHILIA A Unstable ANGINA Dual ANTIPLATELET THERAPY Drug eluting stent COAGULATION factors replacement THERAPY
• 年，卷（期）: 2017,（2）
• 页码范围: 28-31
• 页数: 4页
• 分类号: R

摘要

Hemophilia A is an X-linked recessive disorder characterized by a deficiency of coagulation factor VIII(FVIII)and therefore by a greater risk of bleeding during percutaneous interventional procedures and during the dual antiplatelet therapy(DAPT)in patients with ischemic heart disease.Information regarding safe percutaneous procedures in hemophiliacs is limited.Since the introduction of FVVIII concentrates,the life expectancy of hemophiliac patients has improved and consequently,the rate of ischemic heart disease in this population is increased.Frequently the replacement therapy can trigger the onset of an acute coronary syndrome.We report a case of a patient with mild Hemophilia A,who presents with unstable angina,treated successfully with coronary angioplasty and drug eluting stent implantation without replacement of FVVIII,treated with long term DAPT without major bleeding after six months of follow up.