Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis

• 作者: Go Okumura Hiroshige Sano Junichi Fujisawa Katsumitsu Arai Naoki Kondo Naoto Endo Takahiro Netsu Tomotake Kanai Yasufumi Kijima
• 来源期刊: 风湿病与自身免疫疾病期刊(英文)
• 学科: 医学
• 关键词: TOCILIZUMAB RHEUMATOID ARTHRITIS REACTIVE Oxygen Species Disease Activity SCORE 28
• 年，卷（期）: 2017,（1）
• 页码范围: 46-52
• 页数: 7页
• 分类号: R5

摘要

To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured 392 ± 110 Carratelli units [U. CARR] on initiation of TCZ, and significantly decreased to 237 ± 82, 248 ± 88, and 226 ± 91 U.CARR after 3, 6, and 12 months, respectively (p