Advance of antioxidants in asthma treatment

• 作者: Lin-Yun Zhu Xiong-Biao Wang Xu-Ming Luo Zhen-Hua Ni
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: ASTHMA OXIDATIVE stress REACTIVE OXYGEN species ANTIOXIDANTS
• 年，卷（期）: 2017,（1）
• 页码范围: 17-28
• 页数: 12页
• 分类号: R

摘要

Asthma is an allergic disease,characterized as a recurrent airflow limitation,airway hyperreactivity,and chronic inflammation,involving a variety of cells and cytokines.Reactive oxygen species have been proven to play an important role in asthma.The pathogenesis of oxidative stress in asthma involves an imbalance between oxidant and antioxidant systems that is caused by environment pollutants or endogenous reactive oxygen species from inflammation cells.There is growing evidence that antioxidant treatments that include vitamins and food supplements have been shown to ameliorate this oxidative stress while improving the symptoms and decreasing the severity of asthma.In this review,we summarize recent studies that are related to the mechanisms and biomarkers of oxidative stress,antioxidant treatments in asthma.