Recent advances in the identification of the host factors involved in dengue virus replication

• 来源期刊: 中国病毒学
• 年，卷（期）: 2017,（1）
• 页码范围: 23-31
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s12250-016-3902-6

摘要

Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes.The life cycle of DENV includes attachment,endocytosis,protein translation,RNA synthesis,assembly,egress,and maturation.Recent researches have indicated that a variety of host factors,including cellular proteins and microRNAs,positively or negatively regulate the DENV replication process.This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.