Evaluation of atherosclerotic lesions in cholesterol-fed mice during treatment with paclitaxel in lipid nanoparticles: a magnetic resonance imaging study

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2017,（2）
• 页码范围: 116-121
• 页数: 6页
• 分类号: R95
• 语种: 英文
• DOI: 10.7555/JBR.31.20160123

摘要

Cholesterol-core nanoparticles (LDE) have been shown to be recognized by low-density lipoprotein receptors (LDLR) after administration;therefore,LDE is an ideal vehicle to deliver drug with targeting property.Paclitaxel,when incorporated into LDE,promotes atherosclerosis regression with reduced drug toxicity in rabbits through LDLR.Here,we tested whether LDE-paclitaxel could still be effective in reducing diet-induced atherosclerosis in a mouse model without LDLR.Nineteen LDLR knockout male mice were fed 1％ cholesterol for 12 weeks.Then,12 animals received 4-weekly intraperitoneal LDE-paclitaxel (4 mg/kg) while 7 controls received saline solution.On week 12 and 16,in vivo MRI of the aortic roots was performed.Aorta macroscopy was made after euthanasia.Reduction of atherosclerotic lesions was observed.LDE-paclitaxel treatment resulted in reduction of wall area (14％) and stenosis (22％) by MRI and 33％ by macroscopy.Thus,LDE-paclitaxel may produce pharmacological effects through LDE uptake by mechanisms other than LDLR.