Thermal Decomposition Kinetics of Ursodeoxycholic Acid Drug Crystal

• 作者: E. Ramachandran R. Jeyasudha S. Ramukutty
• 来源期刊: 结晶过程及技术期刊(英文)
• 学科: 化学
• 关键词: THERMAL Analysis THERMAL DECOMPOSITION KINETICS Ursodeoxycholic ACID
• 年，卷（期）: 2017,（4）
• 页码范围: 85-90
• 页数: 6页
• 分类号: O6

摘要

The crystallization of ursodeoxycholic acid drug crystals in gel by reduction of solubility method is the first of its kind to be reported in literature. Monoclinic crystalline form of the structure was confirmed using single crystal X-ray diffraction analysis. This report deals with the kinetic analysis made from the thermogravimetric analysis/differential thermal analysis (TGA/DTA) data using Coats-Redfern (CR) relation. Thermodynamic parameters were also determined. Arrhenius equation for ursodeoxycholic acid was derived as k = 3.10 × 1010 e−172581/RT mol−1•s−1.