Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats

• 作者: Ahmed Abubakar Aliyu Mohammed Ejike Daniel Eze Karimah Mohammed Rabiu Sheu Oluwadare Sulaiman Yusuf Tanko
• 来源期刊: 糖尿病(英文)
• 学科: 医学
• 关键词: Diabetes Mellitus STREPTOZOTOCIN LYCOPENE ERYTHROCYTE OSMOTIC FRAGILITY Lipid PEROXIDATION Rats
• 年，卷（期）: tnbyw_2017,（3）
• 页码范围: 71-85
• 页数: 15页
• 分类号: R5

摘要

Introduction: Diabetes mellitus has remained one of the serious health problems in the world;and oxidative stress has been reported to be a root cause for the progression and development of diabetes mellitus and its associated complications. Aim: This study investigated the possible ameliorative effects of lycopene on diabetic-induced changes in erythrocyte osmotic fragility and lipid peroxidation in Wistar rats. Methodology: The animals were made diabetic by single intraperitoneal injection of streptozotocin at 60 mg/kg b w. Diabetes was confirmed by the presence of high fasting blood glucose level ≥ 200 after 72 hours. Thereafter, diabetic rats were randomly assigned into six groups (1, 2, 3, 4, 5 and 6) comprising five animals each. Group 1 (Diabetic control) and group 2 (Normal control) rats received 0.5 ml of olive oil, groups 3, 4, 5 rats received 10, 20, 40 mg/kg bw of lycopene respectively, while those in group 6 received 2 mg/kg bw of glibenclamide orally once daily for a period of four weeks. At the end of the treatment, all animals were sacrificed;blood samples collected for determination of erythrocyte osmotic fragility (EOF) and lipid peroxidation (LPO). Results: The results obtained showed that there was a significantly (P Conclusion: From the available findings, it can be concluded that administration of lycopene to diabetic rats attenuated diabetic-induced changes in EOF and LPO and these observed effects may be attributed to anti-oxidative property of lycopene.