Onion is one of the most important vegetable crops grown in Uganda, because of its nutritional and economic value.However, production of onion in Uganda is very low due to nutritional imbalances in the soil. Therefore, soil fertility remains one ofthe key areas of focus in sustaining onion production. A field experiment was conducted to assess the response of onion variety RedCreole C-5 to different soil organic amendments at Kyambogo University during the period February 2016 and January 2017. Theexperiment was laid out in a randomized complete block design with four replications. The treatments included To: without manure(control), TI: green manure (GM), T2: farmyard manure (FYM) and T3: compost manure (CM). Data collected included: plant height,root length, plant fresh and dry weight, number of leaves per plant, fresh and dry weight of bulbs, diameter of bulbs and commercialyield computed. Data were analysed using Genstat. There was significant response of onion to the different soil organic amendments.Onion plant height, number of leaves, root length, dry and fresh weight and bulb weight were high in farmyard manure, followed bycompost manure and lastly green manure, compared to the control. The highest yield (12,000 kg/ha) was obtained from the plotsamended with farmyard manure as opposed to the control. It was therefore concluded that farmyard manures had a greater effect onthe agronomic and yield performance of onion. Future study with more than one onion genotype is recommended so as to widen thescope of this result.