Circular RNAs in colorectal cancer: Possible roles in regulation of cancer cells

• 作者: María Isabel Taborda Sebastián Ramírez Giuliano Bernal
• 来源期刊: 世界胃肠肿瘤学杂志：英文版（电子版）
• 学科: 医学
• 关键词: 圆形的 RNA Colorectal 癌症 基因规定 CircRNA 非编码的 RNA 长非编码的 RNA CIRCULARIZATION
• 年，卷（期）: 2017,（2）
• 页码范围: 62-69
• 页数: 8页
• 分类号: R735.34

摘要

Colorectal cancer(CRC) is the third most commonly diagnosed cancer in the world and the fourth principal cause of cancer deaths worldwide. Currently, there is a lack of low cost and noninvasive screening tests for CRC, becoming a serious health problem. In this context, a potential biomarker for the early detection of CRC has recently gained attention. Circular RNAs(circ RNA), a re-discovered, abundant RNA specie, is a type of noncoding covalent closed RNAs formed from both exonic and intronic sequences. These circular molecules are widely expressed in cells, exceeding the abundance of the traditional linear m RNA transcript. They can regulate gene expression, acting as real sponges for mi RNAs and also regulate alternative splicing or act as transcriptional factors and inclusive encoding for proteins. However, little is known about circ RNA and its relationship with CRC. In this review, we focus on the biogenesis, function and role of these circ RNAs in relation to CRC, including their potential as a new biomarker.