Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone

• 作者: Aldo S. de Oliveira Inês M. C. Brighente Juliana S. Ribeiro Lizandra C. Bretanha Luana C. Llanes Pedro H. A. Carvalho Rafael G. Lund Ricardo J. Nunes Rosendo Augusto Yunes
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Napthoquinones ANTIFUNGAL Candida ALBICANS ANTIOXIDANT
• 年，卷（期）: 2017,（2）
• 页码范围: 39-48
• 页数: 10页
• 分类号: R28

摘要

This article reports the evaluation of antioxidant and antifungal activity from synthetic naphthoquinones derived from lawsone. The antifungal activity was carried out through the inhibition of exoenzymes produced by Candida albicans. The inhibition of phospholipase and the proteinase production by Candida was similar in all derivatives tested;however, the difference between the enzyme production of the control and test does not show statistical difference in any of the studied strains. Furthermore, the antioxidant activity using DPPH radical-scavenging assay showed an important activity for all naphtoquinone derivatives.