The Effects of Fe<sub>2</sub>O<sub>3</sub>and B<sub>2</sub>O<sub>3</sub>on the Glass Structural, Thermal, <i>in Vitro</i>Degradation Properties of Phosphate Based Glasses

• 作者: Chao Tan Chenkai Zhu Chris Rudd Jinsong Liu Lizhe He Songling Huang Xiaoling Liu Xiaoye Cong
• 来源期刊: 玻璃与陶瓷期刊(英文)
• 学科: 化学
• 关键词: PHOSPHATE Based GLASS Boron Iron THERMAL Properties DEGRADATION Study
• 年，卷（期）: 2017,（4）
• 页码范围: 100-115
• 页数: 16页
• 分类号: O6

摘要

Currently, phosphate based glasses have been potential future biomaterial for medical application due to excellent cytocompatibility and fully bioresorbability. In this study, phosphate based glass system with composition of 48P2O5-12B2O3-(25-X)MgO-14CaO-1Na2O-(X)Fe2O3 (X = 6, 8, 10) and 45P2O5-(Y)B2O3-(32-Y)MgO-14CaO-1Na2O-8Fe2O3 (Y = 12, 15, 20), was prepared via a melting quenching process. The effect of replacing MgO with Fe2O3 and B2O3 on the structural, thermal, degradation properties of phosphate based glass was investigated. Fourier Transform Infrared (FTIR) spectroscopy and Raman spectroscopy analysis confirmed the polymerisation of phosphate based glass network with addition of Fe2O3, thus the processing window was observed to increase whilst the dissolution rate was reduced, attributed to the formation of Fe-O-P cross-link. As the effect on the glass structure stability was demonstrated by both B2O3 and MgO, the nonlinear variation of thermal stability and degradation behaviour was observed for glass system with substitution of MgO by B2O3. However, due to the lower dissolution rate of glass system when compared to the biocompatible phosphate based glass in preliminary study, the expected cytocompatibility could be confirmed in the downstream activities.