Antihyperglycemic, antihyperlipidemic and antioxidant effects of standard ethanol extract of Bombax ceiba leaves in high-fat-diet-and streptozotocin-induced Type 2 diabetic rats

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2017,（3）
• 页码范围: 168-177
• 页数: 10页
• 分类号: R965
• 语种: 英文
• DOI: 10.3724/SP.J.1009.2017.00168

摘要

The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L.leaves (BCE) in type 2 diabetic mellitus (T2DM).Oral administration of BCE at doses of 70,140,and 280 mg·kg-1,to the normal rats and the high-fat-diet-and streptozotocin-induced T2DM rats were carried out.Effects of BCE on blood glucose,body weight,and a range of serum biochemical parameters were tested,and histopathological observation of pancreatic tissues was also performed.HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin,isoorientin,vitexin,isomangiferin,isovitexin,quercetin hexoside,2'-trans-O-cumaroyl mangiferin,and nigricanside.BCE caused a significant decrease in the concentrations of fasting blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride,low density lipoprotein-cholesterol,serum insulin,and malondialdehyde,and increases in oral glucose tolerance,high density lipoprotein-cholesterol,and superoxide dismutase in the T2DM model rats.Moreover,considerable pancreatic β-cells protection effect and stimulation of insulin secretion from the remaining pancreatic β-cells could be observed after BCE treatment.The results indicated that BCE exhibited an excellent hypoglycemic activity,and alleviated dyslipidemia which is associated with T2DM.Antioxidant activity and protecting pancreatic β-cells are the possible mechanisms involved in anti-diabetic activity of BCE.