Hitting the right button: MAVS-mediated defense against HAV infection

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2017,（1）
• 页码范围: 7-8
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2016.139

摘要

Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems.A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species restriction of infection with hepatitis A virus as well as linking cytosolic immune sensing in infected hepatocytes with innate effector functions and protective adaptive immunity.