Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2017,（3）
• 页码范围: 213-225
• 页数: 13页
• 分类号: R737.9
• 语种: 英文
• DOI: 10.7555/JBR.31.20160087

摘要

Expression of estrogen receptors is correlated with breast cancer risk,but inconsistent results have been reported.To clarify potential estrogen receptor (ESR)-related breast cancer risk,we analyzed genetic variants of ESR1 in association with breast cancer susceptibility.We performed a meta-analysis to investigate the association between rs2234693,rs1801132,and rs2046210 (single nucleotide polymorphisms of ESR1),and breast cancer risk.Our analysis included 44 ease-control studies.For rs2234693,the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype.For rs2046210,the AA,GA,or GA + GG genotype had a much higher risk compared to the GG genotype.No significant association was found for the rs1801132 polymorphism with breast cancer risk.This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk.The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.