Therapeutic Outcome of Botulinum Toxin Type A for Patients with Low Bladder Compliance Secondary to Spinal Cord Injury

• 作者: C. H. Jiang H. Chen J. W. Zeng L. L. Zhou M. P. Huang Q. L. Liu Q. Q. Li T. H. Huang X. Y. Yang
• 来源期刊: 泌尿学期刊(英文)
• 学科: 医学
• 关键词: BOTULINUM TOXIN Type A LOW BLADDER COMPLIANCE Spinal Cord Injury
• 年，卷（期）: mnxqkyw_2017,（11）
• 页码范围: 207-211
• 页数: 5页
• 分类号: R73

摘要

Objective: To evaluate the efficacy and safety of botulinum toxin type A (BTX-A) in treating patients with low bladder compliance (BC) secondary to spinal cord injury (SCI). Methods: From 2011 to 2016, we retrospected patients who received BTX-A injections for LBC secondary to SCI. The primary outcomes were urodynamic parameters including maximum detrusor pressure (Pdetmax), bladder compliance (BC). Related adverse events were recorded. Results: 72 SCI patients were selected (62 males, 10 females, age range 18 - 52 years;mean age 28.5 years). 12 weeks after BTX-A injection, Pdetmax decreased from 51.02 cmH2O to 28.31 cmH2O. BC increased from 3.64 ml/cmH2O to 10.08 ml/cmH2O. 12 patients had mild transient haematuria for 1 - 2 days. Conclusion: Intradetrusor BTX-A injection was effective and safe for patients with low BC secondary to SCI.