Utilizing a microfluidic device to enrich and fluorescently detect circulating tumor cells

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2017,（7）
• 页码范围: 453-455
• 页数: 3页
• 语种: 英文

摘要

Circulating tumor cells (CTCs) are cancer cells that have propagated from primary tumor sites,spreading into the bloodstream as the cellular origin of fatal metastasis,and to secondary tumor sites.Capturing and analyzing CTCs is a kind of "liquid biopsy" of the tumor that provides information about cancer changes over time and tailoring treatment [1].CTC enrichment and detection remains technologically challenging due to their extremely low concentrations in blood (as few as 1 CTC per 1 billion blood cells),which hampers cellular and molecular typing [2].To realize the capture and detection synchronously of CTCs faces greater challenges.