A set of interesting sequoiatones stereoisomers from a wetland soil-derived fungus Talaromyces flavus

• 来源期刊: 药学学报（英文版）
• 关键词: Wetland soil-derived fungus Talaromyces flavus Stereoisomers Sequoiatone Electronic circular dichroism
• 年，卷（期）: 2017,（2）
• 页码范围: 167-172
• 页数: 6页
• 语种: 英文

摘要

Four interesting sequoiatones stereoisomers (1-4) were isolated from a wetland soil-derived fungus Talaromycesflavus by chiral HPLC.On the basis of comprehensive NMR and mass analyses,their planar structures were elucidated as the same as that of sequoiatone B.Among them,1 and 3 (or 2 and 4)were a pair of enantiomers,and 1 and 2 (or 3 and 4) were a pair of stereoisomers with epimerization at C-12,which indicated that sequoiatione-type metabolites exist as enantiomers rather than as optically pure compounds in some strains.With the quantum chemical ECD calculations,the absolute configurations of C-8 in 1-4 were determined,which is the first report to establish the absolute configuration of C-8 in sequoiatones.However,the absolute configurations of C-12 in sequoiatones are still unsolved.