BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2017,（3）
• 页码范围: 209-219
• 页数: 11页
• 语种: 英文
• DOI: 10.1093/jmcb/mjx019

摘要

Extraribosomal functions of ribosomal proteins (RPs) have gained much attention for their implications in tumorigenesis and progression.However,the regulations for transition between the ribosomal and extraribosomal functions of RPs are rarely reported.Herein,we identified a ribosomal protein S7-interacting partner,BCCIPβ,which modulates the functional conversion of S7.Through the N-terminal acidic domain,BCClPβ interacts with the central basic region in S7 and regulates the extraribosomal distribution of S7.BCCIPβ deficiency abrogates the ribosomal accumulation but enhances the ribosome-free location of S7.This translocation further impairs protein synthesis and triggers ribosomal stress.Consequently,BCClPβ deficiency suppresses the ribosomal function and initiates the extraribosomal function of S7,resulting in restriction of cell proliferation.Moreover,clinically relevant S7 mutations were found to dampen the interaction with BCCIPβ and facilitate the functional transition of S7.In conclusion,BCCIPβ,as a S7 modulator,contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development.