In this work,hot isostatic pressing (HIPing) technique was used to densify the Ti2AlNb pre-alloyed powder.The influence of HIPing loading route parameters (temperature and rates of heating and pressurizing) on microstmcture and properties of PM Ti2AlNb alloys was studied.The results showed that HIPing loading route parameters affected the densification process and mechanical properties (especially high temperature rupture lifetime) of PM Ti2AlNb alloys in the present work.A finite element method (FEM) model for predicting the final densification was developed and was used to optimize the HIPing procedure.