Study of the Relationship between Anti-Peroxidase Antibody and Miscarriage, Preterm Labor and IUGR in Egyptian Pregnant Women

• 作者: Ahmed S. El-Halwagy
• 来源期刊: 妇产科期刊(英文)
• 学科: 医学
• 关键词: Thyroid AUTOIMMUNITY Recurrent ABORTION Pretem Labor IUGR
• 年，卷（期）: 2017,（5）
• 页码范围: 494-502
• 页数: 9页
• 分类号: R73

摘要

Background: This research studied the relationship between anti-peroxidase anti-body in euthyroid pregnant female and miscarriage, preterm labor and IUGR in Egyptian patients. Patients and Methods: This prospective study was carried on patients who attended to the Obstetrics and Gynecology department of Tanta University Hospital for routine antenatal care from January 2016 to November 2016. 80 women enrolled in the study and were divided into four groups, 20 cases for each group, a control group, recurrent unexplained abortion group, preterm labor group and IUGR group. A Thyroperoxidase (TPO) antibody was measured in all cases. Results & Discussion: The eighty patients were randomly enrolled into 4 groups, 20 patients in each group. Their age ranged from 20 to 35 years and BMI ranged from 18 to 35. The percentage of +ve TPO Ab of the control group was 5% and of the recurrent abortion group was 20% and of the preterm labor group was 15% and of the IUGR group it was 5%. (P value 0.026) indicating statistically significant correlation between TPO Ab and recurrent unexplained abortion and preterm labor. Conclusion: The presence of (TPO) antibodies could be correlated to recurrent unexplained abortion and preterm labor. More studies are required to determine whether an intervention is needed to treat thyroid autoantibody positivity during pregnancy.