Electrospun PLLA Membranes for Caffeine Delivery: Diffusional Approach

• 作者: Ana Paula S. Immich Francesc Cano Casas José Antonio Tornero Manuel J. Lis Arias
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: DIFFUSION POLYMER Nano Escale KINETICS
• 年，卷（期）: swyxgcyw_2017,（12）
• 页码范围: 563-574
• 页数: 12页
• 分类号: R73

摘要

One of the great advantages of electrospun fibers is the large tridimensional area produced, capable of storing any type of material. The aim of our investigation is to study the electrospinning technique to produce polymer membranes for drug delivery applications, given their large surface area and ability to transport a bioactive compound. A mathematical modeling of the delivery system kinetics was also studied to find the mechanism that controls the releasing process. Results showed that electrospinning could provide regular and smooth membranes suitable for drug delivery processes. The mathematical modeling also proved that thicker PLLA membranes exhibited a Fickian diffusion behavior during the drug transport, presenting better control in drug delivery processes.