The Effect of Granulocyte Macrophage-Colony Stimulating Factor upon the Induction of Peripheral Blood Dendritic and Natural Killer Cells When Given Simultaneously with a Slow Continuous Doxorubicin Infusion

• 作者: Antonio C. Simoes Arthur J. Weiss Irwin L. Stoloff
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: DOXORUBICIN INFUSION DENDRITIC KILLER Cells
• 年，卷（期）: azzlyw_2017,（7）
• 页码范围: 637-644
• 页数: 8页
• 分类号: R73

摘要

It has been demonstrated that it is safe to give Gm-Csf, together with Doxorubicin, by continuous intravenous infusion, thereby substantially increasing the amount of Doxorubicin administered to the average patient, and assuring that each patient receives an individually-determined safe and maximal amount of drug. It is known that Gm-Csf is a potent inducer of components that are major factors in an immunologic attack upon neoplasms. For that reason, we thought it would be worth evaluating in 4 patients’ surface markers of dendritic precursor cells, dendritic cells [DC], and natural killer [NK] cells during the infusion. While there was substantial variation in individual responses, all 4 patients receiving Gm-Csf developed persistent marked increases in cells with each of these markers. The significance of these findings will be discussed.