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摘要:
The superior colliculus (SC) is a laminated midbrain structure responsible for visual orientation behaviors. In the mature SC, neurons in the stratum griseum superficiale (SGS) receive visual inputs that contribute to exciting premotor neurons in the stratum griseum intermediale (SGI) through a dorsoventral pathway. SGI activation generates feedback signals to the SGS through a ventrodorsal pathway. However, the developmental changes in signal transmission within the SC around the time of eye opening are not yet well understood. We compared the functional connections between the SGS and SGI before and after eye opening by imaging the neuronal population responses using a voltage-sensitive absorption dye in mouse SC slices. Electrophoresis of a fluorescent dye from the stimulating electrodes was used to fill the cells in the stimulated site. We here show that the dorsoventral transmission is present both before and after eye opening. This is in contrast to our previous finding that the ventrodorsal transmission develops after eye opening. Functions of intrinsic inhibitory systems mediated by gamma-aminobutyric acid were also investigated with the antagonist. The processes stained by electrophoresis from stimulating electrodes before eye opening were confined within the respective stimulated layers. Whereas, after eye opening, the processes were widely extended especially dorsoventrally and ventrodorsally invading the SGI and SGS, respectively. These corresponded well to the early component of voltage responses that is known to reflect the activation of presynaptic elements, presumably the axonal arborizations and varicosities. Thus, the optically-revealed functional connections between the SGS and SGI were correlated to the morphology.
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篇名 Development of Functional Interlaminar Pathways in the Mouse Superior Colliculus Revealed by Optical Imaging with Axonal Labeling
来源期刊 生物科学与医学(英文) 学科 医学
关键词 AXONAL Projection Optical Imaging SUPERIOR Colliculus Visual Orientation Voltage-Sensitive DYE
年,卷(期) 2017,(8) 所属期刊栏目
研究方向 页码范围 11-35
页数 25页 分类号 R73
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研究主题发展历程
节点文献
AXONAL
Projection
Optical
Imaging
SUPERIOR
Colliculus
Visual
Orientation
Voltage-Sensitive
DYE
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研究来源
研究分支
研究去脉
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期刊影响力
生物科学与医学(英文)
月刊
2327-5081
武汉市江夏区汤逊湖北路38号光谷总部空间
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721
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0
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