Flavanols from the Camellia sinensis var.assamica and their hypoglycemic and hypolipidemic activities

• 来源期刊: 药学学报（英文版）
• 关键词: Camellia sinensis var.assamica Pu-erh tea Flavanol Hypoglycemic Hypolipidemic
• 年，卷（期）: 2017,（3）
• 页码范围: 342-346
• 页数: 5页
• 语种: 英文

摘要

α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia.To identify novel naturally occurring inhibitors,a bioactivity-guided phytochemical research was performed on the pu-erh tea.One new flavanol,named (-)-epicatechin-3-O-(Z)-coumarate (1),and 16 known analogs (2-17) were isolated from the aqueous extract of the pu-erh tea.Their structures were determined by spectroscopic and chemical methods.Furthermore,the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro;compound 15 showed moderate inhibitory effect against sucrase with an IC50 value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC50 value of 1.3 μmol/L.Compounds 8,10,11 and 15 displayed moderate activity against a lipase with IC50 values of 16.0,13.6,19.8,and 13.3 μmol/L,respectively.