Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2017,（11）
• 页码范围: 748-751
• 页数: 4页
• 语种: 英文

摘要

Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported [1].Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typical characteristics of idiosyncratic drug-induced liver injury (IDILI).Human IDILI can be reproduced in animals by drug coexposure to appropriate doses of lipopolysaccharide (LPS),which evokes modest inflammatory stress [2].Many drugs that cause human IDILI,including ranitidine [3] and trovafloxacin [4],can also cause liver injury with a non-hepatotoxic dose in the LPS model.