Synthesis and characterization of pyrimidines analogues as anti-Alzheimer's agents

• 作者: Maan Monika Yadav Divya Yadav Rakesh
• 来源期刊: 中国药学（英文版）
• 学科: 医学
• 年，卷（期）: 2017,（11）
• 所属期刊栏目: 研究论文
• 页码范围: 834-846
• 页数: 13页
• 分类号: R916
• 语种: 英文

摘要

Pyrimidine derivatives have been reported as neuroprotective agents useful for the treatment of various neurodegenerative disorders.In the present study,several pyrimidine analogues have been evaluated as neuroprotective agents in Morris water maze model.It was observed that pyrimidine derivatives 8-17 considerably improve learning,memory,and movement deficits in animal models.Biochemical estimations of brain serum of treated animals revealed suppression of oxidative and nitrosative stress,acetylcholinesterase activity,and other parameters which leads to neurodegeneration of brain.Of all the pyrimidine derivatives,thiomorpholine derivative 8 and piperazine ethanol derivative 17 were found to be the most active neuroprotective agents and produced effects comparable to standard drug rivastigmine in terms of behavioral,biochemical,and molecular aspects.