Synthesis,characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

• 作者: Charmaine Arderne Derek Tantoh Ndinteh Jane Catherine Ngila Marthe Carine Djuidje Fotsing Monisola Itohan Ikhile
• 来源期刊: 中国药学（英文版）
• 学科: 医学
• 年，卷（期）: 2017,（12）
• 所属期刊栏目: 研究论文
• 页码范围: 858-871
• 页数: 14页
• 分类号: R916
• 语种: 英文

摘要

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines.The compounds 1-4 were characterized by spectroscopic and analytical methods.The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only.The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca,having eight molecules in the unit cell,while compound 2 was found to crystallize in the monoclinic crystal system in the space group P21/c.The biological activities of these compounds were investigated by evaluating their antibacterial,antifungal,antimalarial,anti-HIV and anti-trypanosomiasis activities.These compounds displayed very interesting antibacterial,antifungal,antimalarial,anti-trypanosomiasis,anti-HIV and low cytotoxicity activity against HeLa cells.