Protein corona in vivo: dynamic complement proteins-mediated opsonization and immune modulation

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2017,（14）
• 页码范围: 976-977
• 页数: 2页
• 语种: 英文

摘要

It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as "protein corona",which directly interacts with and is recognized by cells.These interactions play a critical role in affecting nanoparticle biological properties,including biodistribution [1],pathophysiology [2],and therapeutic efficacy [3].The compositions of protein corona undergo dynamic exchange in vivo and are highly dependent on the physiochemicai properties of nanoparticles and the physiological microenvironment [4].