IL-12细胞因子家族在变应性鼻炎中的研究进展

• 作者: 刘春苗 尹雪 徐鸥 王建星 董金辉
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: IL-12 鼻炎,变应性 细胞因子类
• 年，卷（期）: 2017,（3）
• 所属期刊栏目: 综述
• 页码范围: 237-241
• 页数: 5页
• 分类号: R765.21
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2017.03.019

摘要

Summary:As the IL-12 family plays an important role in immune regulation,it arouses the attention of the researchers increasingly.There are mainly four members in the IL-12 family,including IL-12,IL-23,IL-27 and IL-35 at present.The family members share many similar structures,but they have their own distinctive biological characteristics and play different roles to balance the functional effects of their own family.IL-12 and IL-23 are positive regulators and mainly play pro-inflammatory effect while IL-27 and IL-35 are negative regulators and mainly play anti-inflammatory effect.Thus,IL-12 family plays an important role in the regulation of the immune response and this function may be better than other cytokine family.IL-12 family has an important regulatory effect on multiple T cell subsets and also has an impact on their differentiation and function.So,we postulate that the IL-12 family may have an intense relationship with the generation and development of the allergic rhinitis.This article will mainly talk about the unique structure and role of the IL-12 cytokine family and discuss its immune regulation effect in the allergic rhinitis.