From glucose sensing to a unified model of AMPK and mTOR regulation

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2017,（18）
• 页码范围: 1233-1234
• 页数: 2页
• 语种: 英文

摘要

The AMP-activated protein kinase (AMPK) is a central energy sensor conserved in most eukaryotes [1].It is able to sense acute drops in cellular energy signaled by elevated ratios of AMP/ADP:ATP and respond with a multifaceted approach that increases energy supply,reduces energy consumption,and replenishes cellular energy stock.Bona fide AMPK targets regulate all aspects of glucose,lipid,and amino acid metabolism,as well as autophagy,mitochondria dynamics and biogenesis,neuronal excitability,and even circadian rhythm [2].