Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2017,（24）
• 页码范围: 1634-1636
• 页数: 3页
• 语种: 英文

摘要

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen that causes reproductive failure and respiratory disease in pigs,resulting in devastating economic losses worldwide [1].Porcine alveolar macrophages (PAMs) are the primary target cells of PRRSV [2],and the putative receptors,including CD163,CD169,and CD151,play key roles during infection [3-6].However,the understanding of PRRSV infection and pathogenesis is limited by its narrow host range.Pig is the unparalleled animal susceptible to PRRSV,but not well-suited for the study of long-term chronic infection or immune response in vivo because of their long breeding cycle,size,high cost,and lack of biological materials.The pathogenesis of PRRSV infection and the mechanism of the host immune response remain largely unclear,due to the lack of small animal models [7].We previously developed a stable transgenic (Tg) cell line co-expressing the porcine CD163 (pCD163),porcine CD169 (pCD169) and simian CD151 (sCD151) receptors that displayed high susceptibility to PRRSV infection [8].