神经营养素3及其受体在大鼠耳蜗螺旋神经节发育中的作用研究进展

• 作者: 郭春飞 金永德 金玉莲
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: 神经营养素3 大鼠 耳蜗 螺旋神经节
• 年，卷（期）: 2017,（12）
• 所属期刊栏目: 综述
• 页码范围: 968-971
• 页数: 4页
• 分类号: R764
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2017.12.021

摘要

Neurotrophin-3(NT-3)attracted increasing attention about NTFs researches in recent years.But the mechanism of promoting the development of neurons and neurite extension is not clear.Recombinant human NT-3 or NT-3 gene is commonly used in the treatment of peripheral and central neurons system damage.When rats are born,the cochlear is not mature yet.It is a suitable experimental animal for studying the morphological and functional development of the peripheral auditory pathway.It was found that NT-3 could promote the survival,growth,division and extension of the cochlear neurons in rats.To make clear the role of NT-3 in the development of spiral ganglion in the rat cochlear will be of significance for the treatment of nervous hearing loss by NT-3 in the future.