AIM:To evaluate and compare the clinical outcomes with a diffractive bifocal and trifocal intraocular lens(IOL) during a 12-month follow-up.METHODS:Prospective comparative study including 75 eyes of 38 patients(44-70 y) undergoing uneventful cataract surgery.Each patient was randomly assigned to one type of IOL,bifocal(35 eyes) or trifocal(40 eyes).Visual,refractive,and contrast sensitivity changes were evaluated in a 12-month follow-up.The binocular defocus curve was also measured at 12 mo postoperatively.RESULTS:No statistically significant differences between groups were found in postoperative uncorrected and corrected distance visual acuities(P≥0.276).Postoperative corrected near visual acuity(33 cm) was significantly better in the trifocal group during all follow-up(P≤0.004) as well as 6-month uncorrected near(P=0.008) and distancecorrected near visual acuities(P=0.016)(33/40 cm).Significantly better uncorrected intermediate and distance corrected-intermediate visual acuity were found during all follow-up in the trifocal group(P<0.001),which was consistent with differences among groups in binocular defocus curve.Differences among groups in contrast sensitivity were minimal,being only significant at 6 months for some low to medium spatial frequencies(P≤0.006).CONCLUSION:Bifocal and trifocal diffractive IOLs are able to provide an effective visual restoration which is maintained during a 12-month follow-up,with a clear benefit of the trifocal IOL for the intermediate vision.