Changes in intraocular pressure and central corneal thickness during pregnancy： a systematic review and Meta-analysis

• 作者: Ai-Ling Li Chao Wang Ling Yu Ying-Qing Lei Yu Pang
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: gjykzzywb_2017,（10）
• 页码范围: 1573-1579
• 页数: 7页
• 分类号: R77

摘要

AIM:To conduct a Meta-analysis for investigating the variations in intraocular pressure(IOP) and central corneal thickness(CCT) during normal pregnancy.METHODS:We searched for clinical trials published up to November 2015 without language or region restrictions in Pub Med,EMBASE,Web of Science,the Cochrane Central Register of Controlled Trials,Ovid,EBSCO,Elsevier,the Chinese Biomedicine Database,Wan Fang,CNKI,CQVIP and Google Scholar.Studies of the ocular changes observed in pregnant women were selected.The main outcomes were assessed by changes in IOP and CCT.RESULTS:Fifteen studies were included.In subgroup analyses,IOP was significantly decreased during the second MD=-1.53,95%CI(-2.19,-0.87);P<0.00001,and third MD=-2.91,95%CI(-3.74,-2.08);P<0.00001 trimesters of pregnancy.CCT was increased during the second MD=10.12,95%CI(2.01,18.22);P=0.01,trimester of pregnancy;moreover,during the third trimester of pregnancy,the CCT displayed an increasing trend,but the difference was not significant MD=5.98,95%CI(-1.11,13.07);P=0.1.CONCLUSION:A decrease in IOP is accompanied by an increase in CCT in the second and third trimesters of a normal pregnancy in women.