头颈鳞状细胞癌化疗耐药分子机制研究进展

• 作者: 赵艳霞
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: 头颈部肿瘤 癌,鳞状细胞 化疗耐药 分子机制
• 年，卷（期）: 2017,（11）
• 所属期刊栏目: 综述
• 页码范围: 888-891
• 页数: 4页
• 分类号: R739.91
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2017.11.018

摘要

Head and neck squamous cell carcinoma(HNSCC) is an aggressive neoplasm with the properties of local recurrence and distant metastasis.Currently,cisplatin-based chemotherapy or concurrent radiochemotherapy is still the first choice or the treatment of advanced HNSCC.However,chemoresistance greatly limited the effectiveness of chemotherapy.Therefore,illustrating the mechanisms of chemoresistance is very important for the treatment of HNSCC.In this article,we summarize the molecular mechanisms of chemoresitance in HNSCC from the perspective of drug efflux,apoptosis,DNA damage and repair,epithelial mesenchymal transition and autophagy.